1t76

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[[Image:1t76.png|left|200px]]
 
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{{STRUCTURE_1t76| PDB=1t76 | SCENE= }}
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==Crystal structure of the androgen receptor ligand binding domain in complex with a WxxVW motif==
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<StructureSection load='1t76' size='340' side='right'caption='[[1t76]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1t76]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T76 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t76 OCA], [https://pdbe.org/1t76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t76 RCSB], [https://www.ebi.ac.uk/pdbsum/1t76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t76 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ANDR_PANTR ANDR_PANTR] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2.Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t7/1t76_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t76 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the androgen receptor ligand binding domain in complex with a WxxVW motif===
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==See Also==
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*[[Androgen receptor 3D structures|Androgen receptor 3D structures]]
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{{ABSTRACT_PUBMED_15328534}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1t76]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T76 OCA].
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==Reference==
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<ref group="xtra">PMID:015328534</ref><references group="xtra"/>
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[[Category: Pan troglodytes]]
[[Category: Pan troglodytes]]
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[[Category: Buehrer, B M.]]
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[[Category: Buehrer BM]]
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[[Category: Fletterick, R J.]]
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[[Category: Fletterick RJ]]
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[[Category: Gron, H.]]
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[[Category: Gron H]]
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[[Category: Hur, E.]]
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[[Category: Hur E]]
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[[Category: Payne, E S.]]
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[[Category: Payne ES]]
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[[Category: Pfaff, S J.]]
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[[Category: Pfaff SJ]]
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[[Category: Af-2]]
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[[Category: Alpha-helical sandwich]]
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[[Category: Androgen]]
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[[Category: Dht]]
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[[Category: Hormone-growth factor receptor complex]]
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[[Category: Ligand binding domain]]
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[[Category: Nuclear receptor]]
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[[Category: Testosterone]]
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[[Category: Transcription factor]]
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Current revision

Crystal structure of the androgen receptor ligand binding domain in complex with a WxxVW motif

PDB ID 1t76

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