1t1v

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[[Image:1t1v.png|left|200px]]
 
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{{STRUCTURE_1t1v| PDB=1t1v | SCENE= }}
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==Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution==
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<StructureSection load='1t1v' size='340' side='right'caption='[[1t1v]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1t1v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T1V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1v OCA], [https://pdbe.org/1t1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t1v RCSB], [https://www.ebi.ac.uk/pdbsum/1t1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t1v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SH3L3_MOUSE SH3L3_MOUSE] Could act as a modulator of glutaredoxin biological activity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t1v ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the 1.6 Angstrom resolution crystal structure of SH3BGRL3, a member of a new mammalian protein family of unknown function. The observed "thioredoxin fold" of SH3BGRL3 matches the tertiary structure of glutaredoxins, even in the N-terminal region where the sequence similarity between the two protein families is negligible. In particular, SH3BGRL3 displays structural modifications at the N-terminal Cys-x-x-Cys loop, responsible for glutathione binding and catalysis in glutaredoxins. The loop hosts a six residue insertion, yielding an extra N-terminal-capped helical turn, first observed here for the thioredoxin fold. This, together with deletion of both Cys residues, results in a substantial reshaping of the neighboring cleft, where glutathione is hosted in glutaredoxins. While not active in redox reaction and glutathione binding, SH3BGRL3 may act as an endogenous modulator of glutaredoxin activities by competing, with its fully conserved thioredoxin fold, for binding to yet unknown target proteins.
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===Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution===
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Crystal structure of the glutaredoxin-like protein SH3BGRL3 at 1.6 Angstrom resolution.,Nardini M, Mazzocco M, Massaro A, Maffei M, Vergano A, Donadini A, Scartezzini P, Bolognesi M Biochem Biophys Res Commun. 2004 May 28;318(2):470-6. PMID:15120624<ref>PMID:15120624</ref>
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{{ABSTRACT_PUBMED_15120624}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1t1v" style="background-color:#fffaf0;"></div>
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[[1t1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1V OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015120624</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolognesi M]]
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[[Category: Donadini, A.]]
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[[Category: Donadini A]]
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[[Category: Maffei, M.]]
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[[Category: Maffei M]]
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[[Category: Massaro, M.]]
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[[Category: Massaro M]]
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[[Category: Mazzocco, M.]]
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[[Category: Mazzocco M]]
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[[Category: Nardini, M.]]
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[[Category: Nardini M]]
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[[Category: Scartezzini, M.]]
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[[Category: Scartezzini M]]
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[[Category: Vergano, A.]]
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[[Category: Vergano A]]
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[[Category: Glutaredoxin]]
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[[Category: Protein 3d-structure]]
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[[Category: Signaling protein]]
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[[Category: Thioredoxin fold]]
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[[Category: X-ray crystallography]]
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Current revision

Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution

PDB ID 1t1v

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