1wfw

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[[Image:1wfw.png|left|200px]]
 
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{{STRUCTURE_1wfw| PDB=1wfw | SCENE= }}
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==Solution structure of SH3 domain of mouse Kalirin-9a protein==
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<StructureSection load='1wfw' size='340' side='right'caption='[[1wfw]]' scene=''>
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===Solution structure of SH3 domain of mouse Kalirin-9a protein===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wfw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WFW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_017035239}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wfw OCA], [https://pdbe.org/1wfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wfw RCSB], [https://www.ebi.ac.uk/pdbsum/1wfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wfw ProSAT], [https://www.topsan.org/Proteins/RSGI/1wfw TOPSAN]</span></td></tr>
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==About this Structure==
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</table>
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[[1wfw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFW OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/KALRN_MOUSE KALRN_MOUSE] Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity).[UniProtKB:P97924]
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:017035239</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/1wfw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wfw ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Neuron-specific gdp/gtp exchange factor]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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Current revision

Solution structure of SH3 domain of mouse Kalirin-9a protein

PDB ID 1wfw

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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