1tsp

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[[Image:1tsp.jpg|left|200px]]<br /><applet load="1tsp" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1tsp, resolution 2.0&Aring;" />
 
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'''CRYSTAL STRUCTURE OF P22 TAILSPIKE PROTEIN: INTERDIGITATED SUBUNITS IN A THERMOSTABLE TRIMER'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF P22 TAILSPIKE PROTEIN: INTERDIGITATED SUBUNITS IN A THERMOSTABLE TRIMER==
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The tailspike protein (TSP) of Salmonella typhimurium phage P22 is a part of the apparatus by which the phage attaches to the bacterial host and hydrolyzes the O antigen. It has served as a model system for genetic and biochemical analysis of protein folding. The x-ray structure of a shortened TSP (residues 109 to 666) was determined to a 2.0 angstrom resolution. Each subunit of the homotrimer contains a large parallel beta helix. The interdigitation of the polypeptide chains at the carboxyl termini is important to protrimer formation in the folding pathway and to thermostability of the mature protein.
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<StructureSection load='1tsp' size='340' side='right'caption='[[1tsp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tsp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_virus_P22 Salmonella virus P22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TSP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tsp OCA], [https://pdbe.org/1tsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tsp RCSB], [https://www.ebi.ac.uk/pdbsum/1tsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tsp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIBER_BPP22 FIBER_BPP22] Structural component of the short non-contractile tail. The tail comprises six fibers that mediate primary attachment to the host cell lipopolysaccharides (LPS) and display endorhamnosidase enzymatic activity, hydrolyzing the alpha-1,3-O-glycosidic linkage between rhamnose and galactose of the O-antigen polysaccharide. Digestion of the LPS brings the capsid near the cell outer membrane.<ref>PMID:12837775</ref> <ref>PMID:20817910</ref>
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==About this Structure==
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==See Also==
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1TSP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_phage_py54 Yersinia phage py54]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSP OCA].
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*[[Tailspike protein 3D structures|Tailspike protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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Crystal structure of P22 tailspike protein: interdigitated subunits in a thermostable trimer., Steinbacher S, Seckler R, Miller S, Steipe B, Huber R, Reinemer P, Science. 1994 Jul 15;265(5170):383-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8023158 8023158]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Yersinia phage py54]]
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[[Category: Large Structures]]
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[[Category: Huber, R.]]
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[[Category: Salmonella virus P22]]
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[[Category: Miller, S.]]
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[[Category: Huber R]]
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[[Category: Reinemer, P.]]
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[[Category: Miller S]]
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[[Category: Seckler, R.]]
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[[Category: Reinemer P]]
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[[Category: Steinbacher, S.]]
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[[Category: Seckler R]]
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[[Category: Steipe, B.]]
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[[Category: Steinbacher S]]
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[[Category: late protein]]
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[[Category: Steipe B]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:16:54 2008''
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Current revision

CRYSTAL STRUCTURE OF P22 TAILSPIKE PROTEIN: INTERDIGITATED SUBUNITS IN A THERMOSTABLE TRIMER

PDB ID 1tsp

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