1thq

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[[Image:1thq.png|left|200px]]
 
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{{STRUCTURE_1thq| PDB=1thq | SCENE= }}
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==Crystal Structure of Outer Membrane Enzyme PagP==
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<StructureSection load='1thq' size='340' side='right'caption='[[1thq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Crystal Structure of Outer Membrane Enzyme PagP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1thq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1THQ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15272304}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1thq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1thq OCA], [https://pdbe.org/1thq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1thq RCSB], [https://www.ebi.ac.uk/pdbsum/1thq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1thq ProSAT]</span></td></tr>
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[[1thq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THQ OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/PAGP_ECOLI PAGP_ECOLI] PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16:0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3-hydroxymyristate chain at position 2 of lipid A (endotoxin). Modifications of lipid A with a palmitate chain allow to evade host immune defenses by resisting antimicrobial peptides and attenuating the inflammatory response to infection triggered by lipopolysaccharide through the Toll-like receptor 4 (TLR4) signal transduction pathway. Phosphatidylglycerol (PtdGro), phosphatidylethanolamine (PtdEtn), phosphatidylserine (PtdSer) and phosphatidic acid (Ptd-OH) are all effective acyl donors.<ref>PMID:11013210</ref>
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<ref group="xtra">PMID:015272304</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/th/1thq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1thq ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Ahn, V E.]]
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[[Category: Large Structures]]
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[[Category: Bishop, R E.]]
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[[Category: Ahn VE]]
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[[Category: Chen, L.]]
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[[Category: Bishop RE]]
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[[Category: Engel, C K.]]
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[[Category: Chen L]]
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[[Category: Hwang, P M.]]
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[[Category: Engel CK]]
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[[Category: Kay, L E.]]
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[[Category: Hwang PM]]
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[[Category: Lo, E I.]]
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[[Category: Kay LE]]
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[[Category: Prive, G G.]]
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[[Category: Lo EI]]
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[[Category: Beta-barrel]]
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[[Category: Prive GG]]
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[[Category: Outer membrane enzyme]]
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[[Category: Pagp]]
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[[Category: Palmitoyltransferase]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Outer Membrane Enzyme PagP

PDB ID 1thq

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