1syx

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[[Image:1syx.png|left|200px]]
 
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{{STRUCTURE_1syx| PDB=1syx | SCENE= }}
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==The crystal structure of a binary U5 snRNP complex==
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<StructureSection load='1syx' size='340' side='right'caption='[[1syx]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1syx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SYX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.345&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1syx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1syx OCA], [https://pdbe.org/1syx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1syx RCSB], [https://www.ebi.ac.uk/pdbsum/1syx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1syx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TXN4A_HUMAN TXN4A_HUMAN] Essential role in pre-mRNA splicing.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sy/1syx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1syx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The bifunctional protein U5-52K is associated with the spliceosomal 20 S U5 snRNP, and it also plays a role in immune response as CD2 receptor binding protein 2 (CD2BP2). U5-52K binds to the CD2 receptor via its GYF-domain specifically recognizing a proline-rich motif on the cytoplasmic surface of the receptor. The GYF-domain is also mediating the interaction of the proteins U5-52K and U5-15K within the spliceosomal U5 snRNP. Here we report the crystal structure of the complex of GYF-domain and U5-15K protein revealing the structural basis for the bifunctionality of the U5-52K protein. The complex structure unveils novel interaction sites on both proteins, as neither the polyproline-binding site of the GYF-domain nor the common ligand-binding cleft of thioredoxin-like proteins, to which U5-15K belongs, are involved in the interaction of U5-15K and U5-52K.
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===The crystal structure of a binary U5 snRNP complex===
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Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2).,Nielsen TK, Liu S, Luhrmann R, Ficner R J Mol Biol. 2007 Jun 15;369(4):902-8. Epub 2007 Apr 4. PMID:17467737<ref>PMID:17467737</ref>
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{{ABSTRACT_PUBMED_17467737}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1syx" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[1syx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SYX OCA].
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*[[U5-15kD|U5-15kD]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017467737</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ficner, R.]]
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[[Category: Large Structures]]
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[[Category: Liu, S.]]
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[[Category: Ficner R]]
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[[Category: Luhrmann, R.]]
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[[Category: Liu S]]
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[[Category: Nielsen, T K.]]
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[[Category: Luhrmann R]]
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[[Category: Gyf-domain]]
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[[Category: Nielsen TK]]
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[[Category: Spliceosomal protein]]
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[[Category: Thioredoxin-like]]
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[[Category: Translation-immune system complex]]
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Current revision

The crystal structure of a binary U5 snRNP complex

PDB ID 1syx

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