1t1s
From Proteopedia
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| - | [[Image:1t1s.png|left|200px]] | ||
| - | + | ==Crystal Structure of the Reductoisomerase Complexed with a Bisphosphonate== | |
| + | <StructureSection load='1t1s' size='340' side='right'caption='[[1t1s]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1t1s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T1S FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBQ:[(5-CHLORO-PYRIDIN-2-YLAMINO)-PHOSPHONO-METHYL]-PHOSPHONIC+ACID'>CBQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1s OCA], [https://pdbe.org/1t1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t1s RCSB], [https://www.ebi.ac.uk/pdbsum/1t1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t1s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DXR_ECOLI DXR_ECOLI] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1s_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t1s ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | [[ | + | |
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Hara | + | [[Category: Large Structures]] |
| - | [[Category: Jomaa | + | [[Category: Hara K]] |
| - | [[Category: Ohsawa | + | [[Category: Jomaa H]] |
| - | [[Category: Oldfield | + | [[Category: Ohsawa K]] |
| - | [[Category: Sanders | + | [[Category: Oldfield E]] |
| - | [[Category: Wiesner | + | [[Category: Sanders JM]] |
| - | [[Category: Yajima | + | [[Category: Wiesner J]] |
| - | [[Category: Yin | + | [[Category: Yajima S]] |
| - | + | [[Category: Yin F]] | |
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Current revision
Crystal Structure of the Reductoisomerase Complexed with a Bisphosphonate
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Categories: Escherichia coli | Large Structures | Hara K | Jomaa H | Ohsawa K | Oldfield E | Sanders JM | Wiesner J | Yajima S | Yin F
