1u5f

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[[Image:1u5f.png|left|200px]]
 
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{{STRUCTURE_1u5f| PDB=1u5f | SCENE= }}
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==Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues==
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<StructureSection load='1u5f' size='340' side='right'caption='[[1u5f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1u5f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[1u5f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5F OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5f OCA], [https://pdbe.org/1u5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5f RCSB], [https://www.ebi.ac.uk/pdbsum/1u5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SKAP2_MOUSE SKAP2_MOUSE] May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.<ref>PMID:11063873</ref> <ref>PMID:15894167</ref> <ref>PMID:16135797</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5f ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Eck, M J.]]
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[[Category: Eck MJ]]
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[[Category: Neel, B G.]]
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[[Category: Neel BG]]
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[[Category: Swanson, K D.]]
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[[Category: Swanson KD]]
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[[Category: Tang, Y.]]
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[[Category: Tang Y]]
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[[Category: Artefactual dimerization induced by vector-derived sequence]]
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[[Category: Ph domain of skap-hom]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues

PDB ID 1u5f

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