1wma

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[[Image:1wma.png|left|200px]]
 
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{{STRUCTURE_1wma| PDB=1wma | SCENE= }}
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==Crystal structure of human CBR1 in complex with Hydroxy-PP==
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<StructureSection load='1wma' size='340' side='right'caption='[[1wma]], [[Resolution|resolution]] 1.24&Aring;' scene=''>
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===Crystal structure of human CBR1 in complex with Hydroxy-PP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wma]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WMA FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15799708}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.24&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AB3:3-(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)PHENOL'>AB3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wma OCA], [https://pdbe.org/1wma PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wma RCSB], [https://www.ebi.ac.uk/pdbsum/1wma PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wma ProSAT]</span></td></tr>
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[[1wma]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMA OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CBR1_HUMAN CBR1_HUMAN] NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.<ref>PMID:18449627</ref> <ref>PMID:15799708</ref> <ref>PMID:17912391</ref> <ref>PMID:18826943</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/1wma_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wma ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Carbonyl reductase|Carbonyl reductase]]
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*[[Carbonyl reductase 3D structures|Carbonyl reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015799708</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bateman, R.]]
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[[Category: Large Structures]]
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[[Category: Rauh, D.]]
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[[Category: Bateman R]]
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[[Category: Shokat, K M.]]
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[[Category: Rauh D]]
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[[Category: Oxidoreductase]]
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[[Category: Shokat KM]]

Current revision

Crystal structure of human CBR1 in complex with Hydroxy-PP

PDB ID 1wma

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