1y3a

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[[Image:1y3a.png|left|200px]]
 
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{{STRUCTURE_1y3a| PDB=1y3a | SCENE= }}
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==Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange==
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<StructureSection load='1y3a' size='340' side='right'caption='[[1y3a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1y3a]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y3A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y3a OCA], [https://pdbe.org/1y3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y3a RCSB], [https://www.ebi.ac.uk/pdbsum/1y3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y3a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y3/1y3a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y3a ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Heterotrimeric G proteins are molecular switches that regulate numerous signaling pathways involved in cellular physiology. This characteristic is achieved by the adoption of two principal states: an inactive, GDP bound state and an active, GTP bound state. Under basal conditions, G proteins exist in the inactive, GDP bound state; thus, nucleotide exchange is crucial to the onset of signaling. Despite our understanding of G protein signaling pathways, the mechanism of nucleotide exchange remains elusive. We employed phage display technology to identify nucleotide state-dependent Galpha binding peptides. Herein, we report a GDP-selective Galpha binding peptide, KB-752, that enhances spontaneous nucleotide exchange of Galpha(i) subunits. Structural determination of the Galpha(i1)/peptide complex reveals unique changes in the Galpha switch regions predicted to enhance nucleotide exchange by creating a GDP dissociation route. Our results cast light onto a potential mechanism by which Galpha subunits adopt a conformation suitable for nucleotide exchange.
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===Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange===
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Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.,Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP Structure. 2005 Jul;13(7):1069-80. PMID:16004878<ref>PMID:16004878</ref>
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{{ABSTRACT_PUBMED_16004878}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1y3a" style="background-color:#fffaf0;"></div>
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[[1y3a]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y3A OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016004878</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blaesius, R.]]
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[[Category: Large Structures]]
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[[Category: Bodor, E T.]]
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[[Category: Blaesius R]]
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[[Category: Fredericks, Z.]]
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[[Category: Bodor ET]]
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[[Category: Harden, T K.]]
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[[Category: Fredericks Z]]
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[[Category: Jezyk, M R.]]
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[[Category: Harden TK]]
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[[Category: Johnston, C A.]]
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[[Category: Jezyk MR]]
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[[Category: Jones, M B.]]
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[[Category: Johnston CA]]
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[[Category: Ramer, J K.]]
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[[Category: Jones MB]]
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[[Category: Siderovski, D P.]]
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[[Category: Ramer JK]]
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[[Category: Sondek, J.]]
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[[Category: Siderovski DP]]
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[[Category: Watts, V J.]]
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[[Category: Sondek J]]
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[[Category: Willard, F S.]]
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[[Category: Watts VJ]]
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[[Category: Protein-peptide complex]]
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[[Category: Willard FS]]
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[[Category: Signaling protein]]
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Current revision

Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

PDB ID 1y3a

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