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1x2h
From Proteopedia
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| - | [[Image:1x2h.png|left|200px]] | ||
| - | + | ==Crystal Structure of Lipate-Protein Ligase A from Escherichia coli complexed with lipoic acid== | |
| - | + | <StructureSection load='1x2h' size='340' side='right'caption='[[1x2h]], [[Resolution|resolution]] 2.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1x2h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X2H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LPA:LIPOIC+ACID'>LPA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x2h OCA], [https://pdbe.org/1x2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x2h RCSB], [https://www.ebi.ac.uk/pdbsum/1x2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x2h ProSAT]</span></td></tr> |
| - | [[1x2h]] is a 3 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/LPLA_ECOLI LPLA_ECOLI] Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Is also able to catalyze very poorly the transfer of lipoyl and octanoyl moiety from their acyl carrier protein.<ref>PMID:7639702</ref> |
| - | < | + | == Evolutionary Conservation == |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/1x2h_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x2h ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Fujiwara | + | [[Category: Large Structures]] |
| - | [[Category: Motokawa | + | [[Category: Fujiwara K]] |
| - | [[Category: Nakagawa | + | [[Category: Motokawa Y]] |
| - | [[Category: Okamura-Ikeda | + | [[Category: Nakagawa A]] |
| - | [[Category: Taniguchi | + | [[Category: Okamura-Ikeda K]] |
| - | [[Category: Toma | + | [[Category: Taniguchi H]] |
| - | + | [[Category: Toma S]] | |
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Current revision
Crystal Structure of Lipate-Protein Ligase A from Escherichia coli complexed with lipoic acid
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