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1urz

From Proteopedia

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[[Image:1urz.png|left|200px]]
 
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{{STRUCTURE_1urz| PDB=1urz | SCENE= }}
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==Low pH induced, membrane fusion conformation of the envelope protein of tick-borne encephalitis virus==
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<StructureSection load='1urz' size='340' side='right'caption='[[1urz]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1urz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus_(WESTERN_SUBTYPE) Tick-borne encephalitis virus (WESTERN SUBTYPE)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1URZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1urz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1urz OCA], [https://pdbe.org/1urz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1urz RCSB], [https://www.ebi.ac.uk/pdbsum/1urz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1urz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q80E47_9FLAV Q80E47_9FLAV]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ur/1urz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1urz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Enveloped viruses enter cells via a membrane fusion reaction driven by conformational changes of specific viral envelope proteins. We report here the structure of the ectodomain of the tick-borne encephalitis virus envelope glycoprotein, E, a prototypical class II fusion protein, in its trimeric low-pH-induced conformation. We show that, in the conformational transition, the three domains of the neutral-pH form are maintained but their relative orientation is altered. Similar to the postfusion class I proteins, the subunits rearrange such that the fusion peptide loops cluster at one end of an elongated molecule and the C-terminal segments, connecting to the viral transmembrane region, run along the sides of the trimer pointing toward the fusion peptide loops. Comparison with the low-pH-induced form of the alphavirus class II fusion protein reveals striking differences at the end of the molecule bearing the fusion peptides, suggesting an important conformational effect of the missing membrane connecting segment.
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===LOW PH INDUCED, MEMBRANE FUSION CONFORMATION OF THE ENVELOPE PROTEIN OF TICK-BORNE ENCEPHALITIS VIRUS===
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Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation.,Bressanelli S, Stiasny K, Allison SL, Stura EA, Duquerroy S, Lescar J, Heinz FX, Rey FA EMBO J. 2004 Feb 25;23(4):728-38. Epub 2004 Feb 12. PMID:14963486<ref>PMID:14963486</ref>
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{{ABSTRACT_PUBMED_14963486}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1urz" style="background-color:#fffaf0;"></div>
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[[1urz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus_(western_subtype) Tick-borne encephalitis virus (western subtype)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URZ OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:014963486</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Bressanelli, S.]]
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[[Category: Large Structures]]
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[[Category: Rey, F A.]]
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[[Category: Bressanelli S]]
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[[Category: Envelope protein]]
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[[Category: Rey FA]]
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[[Category: Membrane fusion]]
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[[Category: Virus-viral protein complex]]
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[[Category: Virus/viral protein]]
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Current revision

Low pH induced, membrane fusion conformation of the envelope protein of tick-borne encephalitis virus

PDB ID 1urz

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