1xb4
From Proteopedia
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| - | [[Image:1xb4.png|left|200px]] | ||
| - | + | ==Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II== | |
| - | + | <StructureSection load='1xb4' size='340' side='right'caption='[[1xb4]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1xb4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XB4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb4 OCA], [https://pdbe.org/1xb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xb4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xb4 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1xb4]] is a 4 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/VPS25_YEAST VPS25_YEAST] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.<ref>PMID:12194858</ref> | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/1xb4_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xb4 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Weissenhorn | + | [[Category: Weissenhorn W]] |
| - | [[Category: Wernimont | + | [[Category: Wernimont AK]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II
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