1sz3

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[[Image:1sz3.png|left|200px]]
 
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{{STRUCTURE_1sz3| PDB=1sz3 | SCENE= }}
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==CRYSTAL STRUCTURE OF NUDIX HYDROLASE DR1025 IN COMPLEXED WITH GNP AND MG+2==
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<StructureSection load='1sz3' size='340' side='right'caption='[[1sz3]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SZ3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sz3 OCA], [https://pdbe.org/1sz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sz3 RCSB], [https://www.ebi.ac.uk/pdbsum/1sz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sz3 ProSAT], [https://www.topsan.org/Proteins/BSGC/1sz3 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Y1025_DEIRA Y1025_DEIRA] Hydrolase that can act as a nucleoside triphosphatase and a dinucleoside polyphosphate pyrophosphatase. The best substrates are 8-oxo-dGTP and 8-oxo-GTP. Other substrates include Ap4A, dGTP and GTP. May be involved in protection from damage caused by radiation.<ref>PMID:23481913</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sz/1sz3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sz3 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF NUDIX HYDROLASE DR1025 IN COMPLEXED WITH GNP AND MG+2===
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==See Also==
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*[[Nudix hydrolase 3D structures|Nudix hydrolase 3D structures]]
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{{ABSTRACT_PUBMED_15123424}}
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*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[1sz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZ3 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015123424</ref><references group="xtra"/>
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[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: BSGC, Berkeley Structural Genomics Center.]]
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[[Category: Large Structures]]
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[[Category: Bessman, M J.]]
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[[Category: Bessman MJ]]
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[[Category: Brenner, S E.]]
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[[Category: Brenner SE]]
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[[Category: Hill, E E.]]
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[[Category: Hill EE]]
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[[Category: Holbrook, E L.]]
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[[Category: Holbrook EL]]
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[[Category: Holbrook, S R.]]
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[[Category: Holbrook SR]]
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[[Category: Mooster, J L.]]
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[[Category: Mooster JL]]
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[[Category: Ranatunga, W.]]
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[[Category: Ranatunga W]]
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[[Category: Schulze-Gahmen, U.]]
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[[Category: Schulze-Gahmen U]]
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[[Category: Xu, W.]]
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[[Category: Xu W]]
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[[Category: Alpha-beta-alpha sandwich]]
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[[Category: Berkeley structural genomics center]]
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[[Category: Bsgc structure funded by nih]]
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[[Category: Hydrolase]]
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[[Category: Nudix fold]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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Current revision

CRYSTAL STRUCTURE OF NUDIX HYDROLASE DR1025 IN COMPLEXED WITH GNP AND MG+2

PDB ID 1sz3

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