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1x9t

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[[Image:1x9t.png|left|200px]]
 
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{{STRUCTURE_1x9t| PDB=1x9t | SCENE= }}
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==The crystal structure of human adenovirus 2 penton base in complex with an ad2 N-terminal fibre peptide==
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<StructureSection load='1x9t' size='340' side='right'caption='[[1x9t]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1x9t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X9T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x9t OCA], [https://pdbe.org/1x9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x9t RCSB], [https://www.ebi.ac.uk/pdbsum/1x9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x9t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSP_ADE02 CAPSP_ADE02] Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein. Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions. Mediates initial virus attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus. As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.<ref>PMID:12221069</ref> <ref>PMID:20615244</ref> <ref>PMID:20798312</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x9/1x9t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x9t ConSurf].
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<div style="clear:both"></div>
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===The crystal structure of human adenovirus 2 penton base in complex with an ad2 N-terminal fibre peptide===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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{{ABSTRACT_PUBMED_15629723}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1x9t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X9T OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015629723</ref><references group="xtra"/>
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[[Category: Human adenovirus 2]]
[[Category: Human adenovirus 2]]
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[[Category: Chroboczek, J.]]
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[[Category: Large Structures]]
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[[Category: Cusack, S.]]
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[[Category: Chroboczek J]]
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[[Category: Schoehn, G.]]
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[[Category: Cusack S]]
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[[Category: Zubieta, C.]]
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[[Category: Schoehn G]]
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[[Category: Anti-parallel beta sheet]]
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[[Category: Zubieta C]]
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[[Category: Insertion domain]]
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[[Category: Jellyroll domain]]
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[[Category: Virus like particle-peptide complex]]
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Current revision

The crystal structure of human adenovirus 2 penton base in complex with an ad2 N-terminal fibre peptide

PDB ID 1x9t

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