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1t1r

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[[Image:1t1r.png|left|200px]]
 
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{{STRUCTURE_1t1r| PDB=1t1r | SCENE= }}
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==Crystal Structure of the Reductoisomerase Complexed with a Bisphosphonate==
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<StructureSection load='1t1r' size='340' side='right'caption='[[1t1r]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1t1r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T1R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMB:[(ISOQUINOLIN-1-YLAMINO)-PHOSPHONO-METHYL]-PHOSPHONIC+ACID'>IMB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1r OCA], [https://pdbe.org/1t1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t1r RCSB], [https://www.ebi.ac.uk/pdbsum/1t1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t1r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DXR_ECOLI DXR_ECOLI] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t1r ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Reductoisomerase Complexed with a Bisphosphonate===
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==See Also==
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*[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]]
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{{ABSTRACT_PUBMED_15339150}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1t1r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1R OCA].
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==Reference==
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<ref group="xtra">PMID:015339150</ref><references group="xtra"/>
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[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Hara, K.]]
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[[Category: Large Structures]]
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[[Category: Jomaa, H.]]
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[[Category: Hara K]]
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[[Category: Ohsawa, K.]]
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[[Category: Jomaa H]]
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[[Category: Oldfield, E.]]
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[[Category: Ohsawa K]]
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[[Category: Sanders, J M.]]
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[[Category: Oldfield E]]
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[[Category: Wiesner, J.]]
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[[Category: Sanders JM]]
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[[Category: Yajima, S.]]
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[[Category: Wiesner J]]
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[[Category: Yin, F.]]
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[[Category: Yajima S]]
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[[Category: Oxidoreductase]]
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[[Category: Yin F]]
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[[Category: Three domain]]
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Current revision

Crystal Structure of the Reductoisomerase Complexed with a Bisphosphonate

PDB ID 1t1r

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