1u0m

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[[Image:1u0m.png|left|200px]]
 
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{{STRUCTURE_1u0m| PDB=1u0m | SCENE= }}
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==Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates==
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<StructureSection load='1u0m' size='340' side='right'caption='[[1u0m]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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===Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1u0m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U0M FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15265863}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u0m OCA], [https://pdbe.org/1u0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u0m RCSB], [https://www.ebi.ac.uk/pdbsum/1u0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u0m ProSAT]</span></td></tr>
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[[1u0m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U0M OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/RPPA_STRCO RPPA_STRCO] Involved in the biosynthesis of melanin but also various secondary metabolites containing a naphthoquinone ring. Catalyzes the iterative condensation of five CoA-linked malonyl units to form a pentaketide intermediate. THNS subsequently catalyzes the dual intramolecular Claisen and aldol condensations of this linear intermediate to produce the fused ring of 1,3,6,8-tetrahydroxynaphthalene (THN).<ref>PMID:12905073</ref> <ref>PMID:15265863</ref>
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<ref group="xtra">PMID:015265863</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Streptomyces coelicolor]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Austin, M B.]]
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Check<jmol>
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[[Category: Bowman, M E.]]
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<jmolCheckbox>
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[[Category: Ferrer, J L.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u0/1u0m_consurf.spt"</scriptWhenChecked>
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[[Category: Izumikawa, M.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Moore, B S.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Noel, J P.]]
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</jmolCheckbox>
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[[Category: Udwary, D W.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u0m ConSurf].
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[[Category: Alpha-beta-alpha-beta-alpha fold]]
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<div style="clear:both"></div>
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[[Category: Bacterial]]
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== References ==
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[[Category: Biosynthetic protein]]
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<references/>
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[[Category: Catalytic triad]]
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__TOC__
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[[Category: Chalcone/stilbene synthase superfamily]]
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</StructureSection>
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[[Category: Chs-like]]
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[[Category: Large Structures]]
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[[Category: Malonyl-coa]]
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[[Category: Austin MB]]
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[[Category: Pk]]
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[[Category: Bowman ME]]
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[[Category: Tetrahydroxynaphthalene synthase]]
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[[Category: Ferrer JL]]
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[[Category: Thiolase fold]]
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[[Category: Izumikawa M]]
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[[Category: Thn]]
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[[Category: Moore BS]]
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[[Category: Type iii polyketide synthase]]
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[[Category: Noel JP]]
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[[Category: Udwary DW]]

Current revision

Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates

PDB ID 1u0m

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