1t7r

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[[Image:1t7r.png|left|200px]]
 
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{{STRUCTURE_1t7r| PDB=1t7r | SCENE= }}
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==Crystal structure of the androgen receptor ligand binding domain in complex with a FxxLF motif==
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<StructureSection load='1t7r' size='340' side='right'caption='[[1t7r]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1t7r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T7R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t7r OCA], [https://pdbe.org/1t7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t7r RCSB], [https://www.ebi.ac.uk/pdbsum/1t7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t7r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ANDR_PANTR ANDR_PANTR] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2.Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t7/1t7r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t7r ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the androgen receptor ligand binding domain in complex with a FxxLF motif===
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==See Also==
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*[[Androgen receptor 3D structures|Androgen receptor 3D structures]]
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{{ABSTRACT_PUBMED_15328534}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1t7r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7R OCA].
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==Reference==
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<ref group="xtra">PMID:015328534</ref><references group="xtra"/>
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[[Category: Pan troglodytes]]
[[Category: Pan troglodytes]]
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[[Category: Buehrer, B M.]]
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[[Category: Buehrer BM]]
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[[Category: Fletterick, R J.]]
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[[Category: Fletterick RJ]]
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[[Category: Gron, H.]]
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[[Category: Gron H]]
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[[Category: Hur, E.]]
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[[Category: Hur E]]
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[[Category: Payne, E S.]]
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[[Category: Payne ES]]
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[[Category: Pfaff, S J.]]
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[[Category: Pfaff SJ]]
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[[Category: Af-2]]
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[[Category: Alpha-helical sandwich]]
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[[Category: Androgen]]
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[[Category: Dht]]
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[[Category: Hormone-growth factor receptor complex]]
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[[Category: Ligand binding domain]]
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[[Category: Nuclear receptor]]
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[[Category: Testosterone]]
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[[Category: Transcription factor]]
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Current revision

Crystal structure of the androgen receptor ligand binding domain in complex with a FxxLF motif

PDB ID 1t7r

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