1t56
From Proteopedia
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| - | [[Image:1t56.png|left|200px]] | ||
| - | + | ==Crystal structure of TetR family repressor M. tuberculosis EthR== | |
| + | <StructureSection load='1t56' size='340' side='right'caption='[[1t56]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1t56]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T56 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t56 OCA], [https://pdbe.org/1t56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t56 RCSB], [https://www.ebi.ac.uk/pdbsum/1t56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t56 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t5/1t56_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t56 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | [[ | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
| - | == | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | < | + | [[Category: Besra GS]] |
| - | [[Category: Mycobacterium tuberculosis]] | + | [[Category: Cocklin SL]] |
| - | [[Category: Besra | + | [[Category: Corsino PE]] |
| - | [[Category: Cocklin | + | [[Category: Daniels IR]] |
| - | [[Category: Corsino | + | [[Category: Dover LG]] |
| - | [[Category: Daniels | + | [[Category: Futterer K]] |
| - | [[Category: Dover | + | [[Category: Tatituri V]] |
| - | [[Category: Futterer | + | |
| - | [[Category: Tatituri | + | |
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Current revision
Crystal structure of TetR family repressor M. tuberculosis EthR
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