1tt9
From Proteopedia
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| - | [[Image:1tt9.png|left|200px]] | ||
| - | + | ==Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamer== | |
| - | + | <StructureSection load='1tt9' size='340' side='right'caption='[[1tt9]], [[Resolution|resolution]] 3.42Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1tt9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TT9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.42Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt9 OCA], [https://pdbe.org/1tt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tt9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tt9 ProSAT]</span></td></tr> |
| - | [[1tt9]] is a 4 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/FTCD_RAT FTCD_RAT] Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity).<ref>PMID:12160147</ref> Binds and promotes bundling of vimentin filaments originating from the Golgi.<ref>PMID:12160147</ref> |
| - | < | + | == Evolutionary Conservation == |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tt/1tt9_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tt9 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Chen | + | [[Category: Chen DH]] |
| - | [[Category: Chiu | + | [[Category: Chiu W]] |
| - | [[Category: Ludtke | + | [[Category: Ludtke SJ]] |
| - | [[Category: Mao | + | [[Category: Mao Y]] |
| - | [[Category: Quiocho | + | [[Category: Quiocho FA]] |
| - | [[Category: Vyas | + | [[Category: Vyas MN]] |
| - | [[Category: Vyas | + | [[Category: Vyas NK]] |
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Current revision
Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamer
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Categories: Large Structures | Rattus norvegicus | Chen DH | Chiu W | Ludtke SJ | Mao Y | Quiocho FA | Vyas MN | Vyas NK
