1why

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1why" [edit=sysop:move=sysop])
Current revision (13:40, 9 May 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1why.png|left|200px]]
 
-
{{STRUCTURE_1why| PDB=1why | SCENE= }}
+
==Solution structure of the RNA recognition motif from hypothetical RNA binding protein BC052180==
-
 
+
<StructureSection load='1why' size='340' side='right'caption='[[1why]]' scene=''>
-
===Solution structure of the RNA recognition motif from hypothetical RNA binding protein BC052180===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1why]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHY FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1why FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1why OCA], [https://pdbe.org/1why PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1why RCSB], [https://www.ebi.ac.uk/pdbsum/1why PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1why ProSAT], [https://www.topsan.org/Proteins/RSGI/1why TOPSAN]</span></td></tr>
-
[[1why]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHY OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RB15B_MOUSE RB15B_MOUSE] RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1.[UniProtKB:Q8NDT2]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/1why_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1why ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Inoue, M.]]
+
[[Category: Inoue M]]
-
[[Category: Kigawa, T.]]
+
[[Category: Kigawa T]]
-
[[Category: Muto, Y.]]
+
[[Category: Muto Y]]
-
[[Category: Nagata, T.]]
+
[[Category: Nagata T]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Shirouzu M]]
-
[[Category: Shirouzu, M.]]
+
[[Category: Terada T]]
-
[[Category: Terada, T.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S.]]
+
-
[[Category: Rbd]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rna binding domain]]
+
-
[[Category: Rna binding protein]]
+
-
[[Category: Rna recognition motif]]
+
-
[[Category: Rnp]]
+
-
[[Category: Rrm]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+

Current revision

Solution structure of the RNA recognition motif from hypothetical RNA binding protein BC052180

PDB ID 1why

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1why"
Personal tools