1wh0
From Proteopedia
(Difference between revisions)
m (Protected "1wh0" [edit=sysop:move=sysop]) |
|||
(6 intermediate revisions not shown.) | |||
Line 1: | Line 1: | ||
- | [[Image:1wh0.png|left|200px]] | ||
- | + | ==Solution structure of the CS domain of human USP19== | |
- | + | <StructureSection load='1wh0' size='340' side='right'caption='[[1wh0]]' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[1wh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WH0 FirstGlance]. <br> | |
- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
- | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wh0 OCA], [https://pdbe.org/1wh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wh0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wh0 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wh0 TOPSAN]</span></td></tr> |
- | [[1wh0]] is a 1 chain structure with sequence from [ | + | </table> |
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/UBP19_HUMAN UBP19_HUMAN] Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.<ref>PMID:19465887</ref> <ref>PMID:21849505</ref> <ref>PMID:22128162</ref> <ref>PMID:22689415</ref> | ||
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
- | [[Category: | + | [[Category: Large Structures]] |
- | [[Category: Inoue | + | [[Category: Inoue M]] |
- | [[Category: Kigawa | + | [[Category: Kigawa T]] |
- | [[Category: Koshiba | + | [[Category: Koshiba S]] |
- | [[Category: Nakanishi | + | [[Category: Nakanishi T]] |
- | + | [[Category: Tochio N]] | |
- | [[Category: Tochio | + | [[Category: Yokoyama S]] |
- | [[Category: Yokoyama | + | |
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + |
Current revision
Solution structure of the CS domain of human USP19
|
Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Nakanishi T | Tochio N | Yokoyama S