1xeu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:50, 14 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1xeu.png|left|200px]]
 
-
{{STRUCTURE_1xeu| PDB=1xeu | SCENE= }}
+
==Crystal Structure of Internalin C from Listeria monocytogenes==
-
 
+
<StructureSection load='1xeu' size='340' side='right'caption='[[1xeu]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-
===Crystal Structure of Internalin C from Listeria monocytogenes===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1xeu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XEU FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_17057330}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xeu OCA], [https://pdbe.org/1xeu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xeu RCSB], [https://www.ebi.ac.uk/pdbsum/1xeu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xeu ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1xeu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEU OCA].
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/INLC_LISMG INLC_LISMG] A virulence enhancer that has at least 2 dissociable functions in infection; it impairs translocation of host transcription factor NF-kappa-B to the nucleus and antagonizes the function of the Tuba dynamin-binding protein, promoting bacterial spreading (PubMed:20855622, PubMed:19767742, PubMed:24332715). Perturbs the morphology of host cell junctions by impairing host DNMBP (Tuba) and WASL interaction, altering cortical tension at the cell junctions and allowing bacteria to more efficiently form bacteria-filled cell protrusions which promote bacterial spreading within infected host tissue (PubMed:19767742, PubMed:24332715). Down-regulates the host inflammation response usually induced by Listeria infection. Interacts with host I-kappa-B kinase alpha (IKKA, CHUK), which prevents IKKA from phosphorylating NF-kappa-B inhibitor alpha (IKBA, NFKBIA) and thus delays degradation of phospho-IKBA. Translocation of host transcription factor p65 (a subunit of NF-kappa-B, RELA) into the nucleus is impaired, which prevents activation of NF-KB-regulated genes (PubMed:20855622). Recognized by serum from healthy humans exposed to L.monocytogenes as well from patients who have recovered from listeriosis (PubMed:9284184).<ref>PMID:19767742</ref> <ref>PMID:20855622</ref> <ref>PMID:24332715</ref> <ref>PMID:9284184</ref>
-
==Reference==
+
== Evolutionary Conservation ==
-
<ref group="xtra">PMID:017057330</ref><references group="xtra"/>
+
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xeu_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xeu ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Listeria monocytogenes]]
[[Category: Listeria monocytogenes]]
-
[[Category: Hussain, S.]]
+
[[Category: Hussain S]]
-
[[Category: Ooi, A.]]
+
[[Category: Ooi A]]
-
[[Category: Pickersgill, R W.]]
+
[[Category: Pickersgill RW]]
-
[[Category: Seyedarabi, A.]]
+
[[Category: Seyedarabi A]]
-
[[Category: Cell invasion]]
+
-
[[Category: Cellular invasion]]
+
-
[[Category: Crystal structure]]
+
-
[[Category: Internalin c]]
+
-
[[Category: Leucine-rich repeat]]
+
-
[[Category: Listeria monocytogene]]
+

Current revision

Crystal Structure of Internalin C from Listeria monocytogenes

PDB ID 1xeu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xeu"
Personal tools