1xrj

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[[Image:1xrj.png|left|200px]]
 
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{{STRUCTURE_1xrj| PDB=1xrj | SCENE= }}
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==Rapid structure determination of human uridine-cytidine kinase 2 using a conventional laboratory X-ray source and a single samarium derivative==
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<StructureSection load='1xrj' size='340' side='right'caption='[[1xrj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Rapid structure determination of human uridine-cytidine kinase 2 using a conventional laboratory X-ray source and a single samarium derivative===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xrj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XRJ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15735337}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xrj OCA], [https://pdbe.org/1xrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xrj RCSB], [https://www.ebi.ac.uk/pdbsum/1xrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xrj ProSAT]</span></td></tr>
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[[1xrj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XRJ OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/UCK2_HUMAN UCK2_HUMAN] Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
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<ref group="xtra">PMID:015735337</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xr/1xrj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xrj ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Uridine kinase]]
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[[Category: Large Structures]]
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[[Category: Appleby, T C.]]
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[[Category: Appleby TC]]
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[[Category: Cheney, I W.]]
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[[Category: Cheney IW]]
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[[Category: Hong, Z.]]
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[[Category: Hong Z]]
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[[Category: Larson, G.]]
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[[Category: Larson G]]
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[[Category: Wu, J Z.]]
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[[Category: Wu JZ]]
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[[Category: Yao, N.]]
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[[Category: Yao N]]
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[[Category: Anomalous]]
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[[Category: Anti-cancer]]
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[[Category: Cancer]]
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[[Category: Nucleoside kinase]]
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[[Category: Oncology]]
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[[Category: Rapid phasing]]
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[[Category: Sad]]
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[[Category: Samarium]]
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[[Category: Single-wavelength]]
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[[Category: Sira]]
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[[Category: Transferase]]
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[[Category: Uck2]]
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[[Category: Uridine-cytidine kinase]]
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Current revision

Rapid structure determination of human uridine-cytidine kinase 2 using a conventional laboratory X-ray source and a single samarium derivative

PDB ID 1xrj

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