1v38

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[[Image:1v38.png|left|200px]]
 
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{{STRUCTURE_1v38| PDB=1v38 | SCENE= }}
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==Solution structure of the Sterile Alpha Motif (SAM) domain of mouse SAMSN1==
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<StructureSection load='1v38' size='340' side='right'caption='[[1v38]]' scene=''>
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===Solution structure of the Sterile Alpha Motif (SAM) domain of mouse SAMSN1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1v38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V38 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v38 OCA], [https://pdbe.org/1v38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v38 RCSB], [https://www.ebi.ac.uk/pdbsum/1v38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v38 ProSAT], [https://www.topsan.org/Proteins/RSGI/1v38 TOPSAN]</span></td></tr>
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[[1v38]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V38 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAMN1_MOUSE SAMN1_MOUSE] Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.<ref>PMID:15381729</ref> <ref>PMID:19923443</ref> <ref>PMID:20478393</ref> <ref>PMID:21296879</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v3/1v38_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v38 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Goroncy, A.]]
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[[Category: Goroncy A]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Kobayashi, N.]]
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[[Category: Kobayashi N]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Hypothetical protein]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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Current revision

Solution structure of the Sterile Alpha Motif (SAM) domain of mouse SAMSN1

PDB ID 1v38

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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