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1utr

From Proteopedia

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[[Image:1utr.png|left|200px]]
 
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{{STRUCTURE_1utr| PDB=1utr | SCENE= }}
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==UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)==
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<StructureSection load='1utr' size='340' side='right'caption='[[1utr]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1utr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UTR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCB:4,4-BIS([H]METHYLSULFONYL)-2,2,5,5-TETRACHLOROBIPHENYL'>PCB</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1utr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1utr OCA], [https://pdbe.org/1utr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1utr RCSB], [https://www.ebi.ac.uk/pdbsum/1utr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1utr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UTER_RAT UTER_RAT] Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ut/1utr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1utr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin, a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds. Breakage of these bonds induces a local unfolding of the N- and C-termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand.
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===UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)===
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Solution structure of a mammalian PCB-binding protein in complex with a PCB.,Hard T, Barnes HJ, Larsson C, Gustafsson JA, Lund J Nat Struct Biol. 1995 Nov;2(11):983-9. PMID:7583672<ref>PMID:7583672</ref>
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{{ABSTRACT_PUBMED_7583672}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1utr" style="background-color:#fffaf0;"></div>
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[[1utr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTR OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:007583672</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Barnes, H J.]]
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[[Category: Barnes HJ]]
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[[Category: Gustafsson, J A.]]
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[[Category: Gustafsson J-A]]
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[[Category: Hard, T.]]
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[[Category: Hard T]]
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[[Category: Larsson, C.]]
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[[Category: Larsson C]]
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[[Category: Lund, J.]]
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[[Category: Lund J]]
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[[Category: Clara cell phospholipid-binding protein]]
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[[Category: Mammalian pcb-binding protein]]
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[[Category: Phospholipase a2 inhibitor]]
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[[Category: Progesterone binding]]
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[[Category: Uteroglobin]]
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Current revision

UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)

PDB ID 1utr

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