1svs

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[[Image:1svs.png|left|200px]]
 
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{{STRUCTURE_1svs| PDB=1svs | SCENE= }}
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==Structure of the K180P mutant of Gi alpha subunit bound to GppNHp.==
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<StructureSection load='1svs' size='340' side='right'caption='[[1svs]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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===Structure of the K180P mutant of Gi alpha subunit bound to GppNHp.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1svs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SVS FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15128951}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1svs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1svs OCA], [https://pdbe.org/1svs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1svs RCSB], [https://www.ebi.ac.uk/pdbsum/1svs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1svs ProSAT]</span></td></tr>
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[[1svs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVS OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
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<ref group="xtra">PMID:015128951</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Heterotrimeric G-protein GTPase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sv/1svs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1svs ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Du, X.]]
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[[Category: Du X]]
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[[Category: Li, P.]]
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[[Category: Li P]]
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[[Category: Ross, E M.]]
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[[Category: Ross EM]]
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[[Category: Sprang, S R.]]
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[[Category: Sprang SR]]
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[[Category: Thomas, C J.]]
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[[Category: Thomas CJ]]
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[[Category: Wang, Y.]]
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[[Category: Wang Y]]
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[[Category: Gi alpha subunit]]
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[[Category: Hydrolase]]
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[[Category: K180p mutation]]
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[[Category: Signaling protein]]
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Current revision

Structure of the K180P mutant of Gi alpha subunit bound to GppNHp.

PDB ID 1svs

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OCA

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