1xhp

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[[Image:1xhp.png|left|200px]]
 
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{{STRUCTURE_1xhp| PDB=1xhp | SCENE= }}
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==Solution Structure of the Extended U6 ISL as Observed in the U2/U6 complex from Saccharomyces cerevisiae==
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<StructureSection load='1xhp' size='340' side='right'caption='[[1xhp]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xhp]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XHP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xhp OCA], [https://pdbe.org/1xhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xhp RCSB], [https://www.ebi.ac.uk/pdbsum/1xhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xhp ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Intron removal in nuclear precursor mRNA is catalyzed through two transesterification reactions by a multi-megaDalton ribonucleoprotein machine called the spliceosome. A complex between U2 and U6 small nuclear RNAs is a core component of the spliceosome. Here we present an NMR structural analysis of a protein-free U2-U6 complex from Saccharomyces cerevisiae. The observed folding of the U2-U6 complex is a four-helix junction, in which the catalytically important AGC triad base-pairs only within U6 and not with U2. The base-pairing of the AGC triad extends the U6 intramolecular stem-loop (U6 ISL), and the NMR structure of this extended U6 ISL reveals structural similarities with domain 5 of group II self-splicing introns. The observed conformation of the four-helix junction could be relevant to the first, but not the second, step of splicing and may help to position the U6 ISL adjacent to the 5' splice site.
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===Solution Structure of the Extended U6 ISL as Observed in the U2/U6 complex from Saccharomyces cerevisiae===
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U2-U6 RNA folding reveals a group II intron-like domain and a four-helix junction.,Sashital DG, Cornilescu G, McManus CJ, Brow DA, Butcher SE Nat Struct Mol Biol. 2004 Dec;11(12):1237-42. Epub 2004 Nov 14. PMID:15543154<ref>PMID:15543154</ref>
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{{ABSTRACT_PUBMED_15543154}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1xhp" style="background-color:#fffaf0;"></div>
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[[1xhp]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHP OCA].
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== References ==
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[[Category: Butcher, S E.]]
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<references/>
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[[Category: Cornilescu, G.]]
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__TOC__
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[[Category: Sashital, D G.]]
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</StructureSection>
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[[Category: Internal bulge]]
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[[Category: Large Structures]]
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[[Category: Metal binding site]]
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[[Category: Butcher SE]]
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[[Category: Penta-loop]]
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[[Category: Cornilescu G]]
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[[Category: Rna]]
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[[Category: Sashital DG]]
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[[Category: Rna stem-loop]]
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[[Category: U6 rna]]
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Current revision

Solution Structure of the Extended U6 ISL as Observed in the U2/U6 complex from Saccharomyces cerevisiae

PDB ID 1xhp

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