1x74

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[[Image:1x74.png|left|200px]]
 
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{{STRUCTURE_1x74| PDB=1x74 | SCENE= }}
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==Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis- mutational and structural characterization of the fold and active site==
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<StructureSection load='1x74' size='340' side='right'caption='[[1x74]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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===Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis- mutational and structural characterization of the fold and active site===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1x74]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X74 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15632186}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x74 OCA], [https://pdbe.org/1x74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x74 RCSB], [https://www.ebi.ac.uk/pdbsum/1x74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x74 ProSAT]</span></td></tr>
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[[1x74]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X74 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/AMACR_MYCTU AMACR_MYCTU] Catalyzes the epimerization of (2R)- and (2S)-methylacyl-coenzyme A (CoA) thioesters (PubMed:15632186, PubMed:19854148, PubMed:26348625). Accepts as substrates a wide range of alpha-methylacyl-CoAs, including (2R)-2-methylmyristoyl-CoA and (2S)-2-methylmyristoyl-CoA, (2R)-pristanoyl-CoA and (2S)-pristanoyl-CoA, and the cholesterol esters (25R)-3-oxo-cholest-4-en-26-oyl-CoA and (25S)-3-oxo-cholest-4-en-26-oyl-CoA (PubMed:15632186, PubMed:26348625). Can also catalyze the interconversion of the non-physiologic substrates (2R)-ibuprofenoyl-CoA and (2S)-ibuprofenoyl-CoA, which are potential competitive inhibitors of the enzyme (PubMed:19854148).<ref>PMID:15632186</ref> <ref>PMID:19854148</ref> <ref>PMID:26348625</ref>
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<ref group="xtra">PMID:015632186</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Alpha-methylacyl-CoA racemase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/1x74_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x74 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Bhaumik, P.]]
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[[Category: Bhaumik P]]
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[[Category: Conzelmann, E.]]
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[[Category: Conzelmann E]]
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[[Category: Hiltunen, J K.]]
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[[Category: Hiltunen JK]]
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[[Category: Kalle, S.]]
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[[Category: Kalle S]]
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[[Category: Kotti, T J.]]
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[[Category: Kotti TJ]]
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[[Category: Schmitz, W.]]
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[[Category: Schmitz W]]
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[[Category: Wierenga, R K.]]
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[[Category: Wierenga RK]]
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[[Category: Alpha-methylacyl-coa racemase]]
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[[Category: Coa transferase]]
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[[Category: Coenzyme some]]
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[[Category: Isomerase]]
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[[Category: Racemase]]
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Current revision

Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis- mutational and structural characterization of the fold and active site

PDB ID 1x74

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