This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1t1t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1t1t" [edit=sysop:move=sysop])
Current revision (08:37, 1 May 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1t1t.png|left|200px]]
 
-
{{STRUCTURE_1t1t| PDB=1t1t | SCENE= }}
+
==Solution Structure of Kurtoxin==
-
 
+
<StructureSection load='1t1t' size='340' side='right'caption='[[1t1t]]' scene=''>
-
===Solution Structure of Kurtoxin===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1t1t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Parabuthus_transvaalicus Parabuthus transvaalicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T1T FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_022329781}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1t OCA], [https://pdbe.org/1t1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t1t RCSB], [https://www.ebi.ac.uk/pdbsum/1t1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t1t ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1t1t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Parabuthus_transvaalicus Parabuthus transvaalicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1T OCA].
+
== Function ==
 +
[https://www.uniprot.org/uniprot/KURT_PARTR KURT_PARTR] Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin acts on Nav1.2/SCN2A. Also binds to Cav3.1/CACNA1G and Cav3.2/CACNA1H T-type calcium channels with high affinity and inhibits the channels by modifying voltage-dependent gating. Another study (PubMed:11896142) shows that it also targets neuronal high-threshold calcium channels, including P-type, N-type, and L-type calcium channels (Cav), and others that still are unidentified pharmacologically.<ref>PMID:10196582</ref> <ref>PMID:11896142</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1t_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t1t ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Parabuthus transvaalicus]]
[[Category: Parabuthus transvaalicus]]
-
[[Category: Cho, E M.]]
+
[[Category: Cho EM]]
-
[[Category: Eu, Y J.]]
+
[[Category: Eu YJ]]
-
[[Category: Kim, J I.]]
+
[[Category: Kim JI]]
-
[[Category: Kohno, T.]]
+
[[Category: Kohno T]]
-
[[Category: Lee, C W.]]
+
[[Category: Lee CW]]
-
[[Category: Min, H J.]]
+
[[Category: Min HJ]]
-
[[Category: Cysteine stabilized alpha-beta]]
+
-
[[Category: Toxin]]
+

Current revision

Solution Structure of Kurtoxin

PDB ID 1t1t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1t1t"
Personal tools