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1tjl

From Proteopedia

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[[Image:1tjl.png|left|200px]]
 
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{{STRUCTURE_1tjl| PDB=1tjl | SCENE= }}
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==Crystal structure of transcription factor DksA from E. coli==
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<StructureSection load='1tjl' size='340' side='right'caption='[[1tjl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal structure of transcription factor DksA from E. coli===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tjl]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TJL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15294156}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjl OCA], [https://pdbe.org/1tjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tjl RCSB], [https://www.ebi.ac.uk/pdbsum/1tjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tjl ProSAT], [https://www.topsan.org/Proteins/RSGI/1tjl TOPSAN]</span></td></tr>
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[[1tjl]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJL OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DKSA_ECOLI DKSA_ECOLI] Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. Binding to RNAP disrupts interaction of RNAP with DNA, inhibits formation of initiation complexes, and amplifies effects of ppGpp and the initiating NTP on rRNA transcription. Inhibits transcript elongation, exonucleolytic RNA cleavage and pyrophosphorolysis, and increases intrinsic termination. Also involved, with RecN, in repair of DNA double-strand breaks.<ref>PMID:15294157</ref> <ref>PMID:15948952</ref> <ref>PMID:16885445</ref> <ref>PMID:22210857</ref> <ref>PMID:15294156</ref>
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<ref group="xtra">PMID:015294156</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tj/1tjl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tjl ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Artsimovitch, I.]]
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[[Category: Large Structures]]
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[[Category: Perederina, A.]]
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[[Category: Artsimovitch I]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Perederina A]]
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[[Category: Svetlov, V.]]
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[[Category: Svetlov V]]
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[[Category: Vassylyev, D G.]]
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[[Category: Vassylyev DG]]
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[[Category: Vassylyeva, M N.]]
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[[Category: Vassylyeva MN]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Dksa]]
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[[Category: Ppgpp]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rna polymerase]]
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[[Category: Rsgi]]
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[[Category: Stringent response]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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Current revision

Crystal structure of transcription factor DksA from E. coli

PDB ID 1tjl

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