1ufg
From Proteopedia
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| - | [[Image:1ufg.gif|left|200px]]<br /><applet load="1ufg" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1ufg" /> | ||
| - | '''Solution structure of immunoglobulin like domain of mouse nuclear lamin'''<br /> | ||
| - | == | + | ==Solution structure of immunoglobulin like domain of mouse nuclear lamin== |
| - | + | <StructureSection load='1ufg' size='340' side='right'caption='[[1ufg]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1ufg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UFG FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ufg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ufg OCA], [https://pdbe.org/1ufg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ufg RCSB], [https://www.ebi.ac.uk/pdbsum/1ufg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ufg ProSAT], [https://www.topsan.org/Proteins/RSGI/1ufg TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LMNA_MOUSE LMNA_MOUSE] Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (By similarity). Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uf/1ufg_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ufg ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Inoue M]] | |
| - | [[Category: Inoue | + | [[Category: Kigawa T]] |
| - | [[Category: Kigawa | + | [[Category: Kobayashi N]] |
| - | [[Category: Kobayashi | + | [[Category: Koshiba S]] |
| - | [[Category: Koshiba | + | [[Category: Yokoyama S]] |
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| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of immunoglobulin like domain of mouse nuclear lamin
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