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1ugv

From Proteopedia

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[[Image:1ugv.jpg|left|200px]]<br /><applet load="1ugv" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ugv" />
 
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'''Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)'''<br />
 
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==Disease==
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==Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)==
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Known diseases associated with this structure: Leukemia, juvenile myelomonocytic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605370 605370]]
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<StructureSection load='1ugv' size='340' side='right'caption='[[1ugv]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1ugv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UGV FirstGlance]. <br>
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1UGV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ugv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugv OCA], [https://pdbe.org/1ugv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ugv RCSB], [https://www.ebi.ac.uk/pdbsum/1ugv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ugv TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[https://omim.org/entry/607785 607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
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== Function ==
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[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN] GTPase-activating protein for RHOA and CDC42.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ug/1ugv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ugv ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Aoki, M.]]
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[[Category: Aoki M]]
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[[Category: Hayashi, F.]]
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[[Category: Hayashi F]]
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[[Category: Hirota, H.]]
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[[Category: Hirota H]]
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[[Category: Inoue, K.]]
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[[Category: Inoue K]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Kikuno, R.]]
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[[Category: Kikuno R]]
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[[Category: Matsuda, T.]]
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[[Category: Matsuda T]]
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[[Category: Matsuo, Y.]]
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[[Category: Matsuo Y]]
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[[Category: Nagase, T.]]
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[[Category: Nagase T]]
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[[Category: Nakayama, M.]]
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[[Category: Nakayama M]]
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[[Category: Ohara, O.]]
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[[Category: Ohara O]]
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[[Category: Osanai, T.]]
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[[Category: Osanai T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Seki E]]
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[[Category: Seki, E.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Tanaka A]]
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[[Category: Tanaka, A.]]
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[[Category: Terada T]]
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[[Category: Terada, T.]]
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[[Category: Yabuki T]]
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[[Category: Yabuki, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoshida M]]
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[[Category: Yoshida, M.]]
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[[Category: beta barrel]]
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[[Category: graf protein]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:24:19 2008''
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Current revision

Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)

PDB ID 1ugv

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