1y8j

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[[Image:1y8j.png|left|200px]]
 
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{{STRUCTURE_1y8j| PDB=1y8j | SCENE= }}
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==Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor==
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<StructureSection load='1y8j' size='340' side='right'caption='[[1y8j]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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===Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1y8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y8J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=STS:2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM'>STS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[1y8j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8J OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y8j OCA], [https://pdbe.org/1y8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y8j RCSB], [https://www.ebi.ac.uk/pdbsum/1y8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y8j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEP_HUMAN NEP_HUMAN] Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.<ref>PMID:2531377</ref> <ref>PMID:15283675</ref> <ref>PMID:20876573</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y8/1y8j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y8j ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Neprilysin|Neprilysin]]
*[[Neprilysin|Neprilysin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Neprilysin]]
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[[Category: Large Structures]]
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[[Category: Aebi, J D.]]
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[[Category: Aebi JD]]
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[[Category: Blum-Kaelin, D.]]
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[[Category: Blum-Kaelin D]]
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[[Category: Bohm, H J.]]
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[[Category: Bohm HJ]]
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[[Category: Dale, G E.]]
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[[Category: Dale GE]]
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[[Category: Diederich, F.]]
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[[Category: Diederich F]]
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[[Category: Frank, B.]]
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[[Category: Frank B]]
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[[Category: Oefner, C.]]
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[[Category: Oefner C]]
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[[Category: Sahli, S.]]
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[[Category: Sahli S]]
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[[Category: Schweizer, W B.]]
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[[Category: Schweizer WB]]
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[[Category: Hydrolase]]
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[[Category: Lt1_6]]
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Current revision

Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor

PDB ID 1y8j

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