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1z83
From Proteopedia
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| - | [[Image:1z83.png|left|200px]] | ||
| - | + | ==Crystal structure of human AK1A in complex with AP5A== | |
| + | <StructureSection load='1z83' size='340' side='right'caption='[[1z83]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1z83]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z83 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AP5:BIS(ADENOSINE)-5-PENTAPHOSPHATE'>AP5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z83 OCA], [https://pdbe.org/1z83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z83 RCSB], [https://www.ebi.ac.uk/pdbsum/1z83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z83 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/KAD1_HUMAN KAD1_HUMAN] Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:[https://omim.org/entry/612631 612631].<ref>PMID:2542324</ref> <ref>PMID:9432020</ref> <ref>PMID:12649162</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KAD1_HUMAN KAD1_HUMAN] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z83_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z83 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Bunkoczi G]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Filippakopoulos | + | [[Category: Filippakopoulos P]] |
| - | [[Category: Jansson | + | [[Category: Jansson A]] |
| - | [[Category: Knapp | + | [[Category: Knapp S]] |
| - | + | [[Category: Schreurs A]] | |
| - | [[Category: Schreurs | + | [[Category: Sundstrom M]] |
| - | [[Category: Sundstrom | + | [[Category: Von Delft F]] |
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Current revision
Crystal structure of human AK1A in complex with AP5A
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