1ypy

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[[Image:1ypy.png|left|200px]]
 
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{{STRUCTURE_1ypy| PDB=1ypy | SCENE= }}
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==Crystal Structure of Vaccinia Virus L1 protein==
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<StructureSection load='1ypy' size='340' side='right'caption='[[1ypy]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ypy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YPY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.51&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ypy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ypy OCA], [https://pdbe.org/1ypy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ypy RCSB], [https://www.ebi.ac.uk/pdbsum/1ypy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ypy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PG095_VACCW PG095_VACCW] Component of the entry fusion complex (EFC), which consists of 11 proteins. During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation.<ref>PMID:34076488</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yp/1ypy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ypy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Although eradicated from nature more than two decades ago, the threat of smallpox has reemerged because of concerns over its use as a biological weapon. We present the structure of the poxvirus L1 protein, a molecule that is conserved throughout the poxvirus family and is nearly identical in vaccinia virus and in variola virus, which causes smallpox. L1 is a myristoylated envelope protein that is a potent target for neutralizing antibodies and an important component of current experimental vaccines. The L1 structure reveals a hydrophobic cavity located adjacent to its N terminus. The cavity would be capable of shielding the myristate moiety, which is essential for virion assembly. The structure of L1 is a step in the elucidation of molecular mechanisms common to all poxviruses that may stimulate the design of safer vaccines and new antipoxvirus drugs.
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===Crystal Structure of Vaccinia Virus L1 protein===
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The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies.,Su HP, Garman SC, Allison TJ, Fogg C, Moss B, Garboczi DN Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4240-5. Epub 2005 Mar 10. PMID:15761054<ref>PMID:15761054</ref>
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{{ABSTRACT_PUBMED_15761054}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1ypy" style="background-color:#fffaf0;"></div>
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[[1ypy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YPY OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015761054</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Vaccinia virus]]
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[[Category: Large Structures]]
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[[Category: Allison, T J.]]
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[[Category: Fogg, C.]]
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[[Category: Garboczi, D N.]]
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[[Category: Garman, S C.]]
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[[Category: Moss, B.]]
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[[Category: Su, H P.]]
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[[Category: L1]]
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[[Category: Orthopox]]
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[[Category: Smallpox]]
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[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
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[[Category: Variola virus]]
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[[Category: Allison TJ]]
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[[Category: Viral protein]]
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[[Category: Fogg C]]
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[[Category: Garboczi DN]]
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[[Category: Garman SC]]
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[[Category: Moss B]]
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[[Category: Su HP]]

Current revision

Crystal Structure of Vaccinia Virus L1 protein

PDB ID 1ypy

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