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1zv7

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[[Image:1zv7.png|left|200px]]
 
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{{STRUCTURE_1zv7| PDB=1zv7 | SCENE= }}
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==A structure-based mechanism of SARS virus membrane fusion==
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<StructureSection load='1zv7' size='340' side='right'caption='[[1zv7]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zv7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/SARS_coronavirus_FRA SARS coronavirus FRA]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZV7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zv7 OCA], [https://pdbe.org/1zv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zv7 RCSB], [https://www.ebi.ac.uk/pdbsum/1zv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zv7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPIKE_SARS SPIKE_SARS] May down-regulate host tetherin (BST2) by lysosomal degradation, thereby counteracting its antiviral activity.<ref>PMID:31199522</ref> Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membrane fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:14670965</ref> <ref>PMID:15496474</ref> Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]<ref>PMID:19321428</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/1zv7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zv7 ConSurf].
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<div style="clear:both"></div>
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===A structure-based mechanism of SARS virus membrane fusion===
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==See Also==
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*[[Sandbox 3001|Sandbox 3001]]
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{{ABSTRACT_PUBMED_16698550}}
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*[[Spike protein 3D structures|Spike protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[1zv7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_fra Sars coronavirus fra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV7 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:016698550</ref><references group="xtra"/>
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[[Category: SARS coronavirus FRA]]
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[[Category: Sars coronavirus fra]]
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[[Category: Dai J]]
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[[Category: Dai, J.]]
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[[Category: Deng Y]]
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[[Category: Deng, Y.]]
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[[Category: Liu J]]
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[[Category: Liu, J.]]
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[[Category: Lu M]]
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[[Category: Lu, M.]]
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[[Category: Yong W]]
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[[Category: Yong, W.]]
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[[Category: Zheng Q]]
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[[Category: Zheng, Q.]]
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[[Category: Coiled coil]]
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[[Category: Conformational change]]
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[[Category: Membrane fusion]]
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[[Category: S2]]
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[[Category: Sars coronavirus]]
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[[Category: Viral protein]]
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[[Category: Virus entry]]
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Current revision

A structure-based mechanism of SARS virus membrane fusion

PDB ID 1zv7

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