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1yok

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[[Image:1yok.png|left|200px]]
 
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{{STRUCTURE_1yok| PDB=1yok | SCENE= }}
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==crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol==
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<StructureSection load='1yok' size='340' side='right'caption='[[1yok]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yok]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YOK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P6L:(2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL+(8E)-OCTADEC-8-ENOATE'>P6L</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yok OCA], [https://pdbe.org/1yok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yok RCSB], [https://www.ebi.ac.uk/pdbsum/1yok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yok ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
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== Function ==
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[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yo/1yok_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yok ConSurf].
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<div style="clear:both"></div>
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===crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol===
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==See Also==
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*[[Liver receptor homolog-1|Liver receptor homolog-1]]
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{{ABSTRACT_PUBMED_15707893}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1yok]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YOK OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015707893</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bynum, J M.]]
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[[Category: Large Structures]]
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[[Category: Fletterick, R J.]]
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[[Category: Bynum JM]]
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[[Category: Guy, R K.]]
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[[Category: Fletterick RJ]]
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[[Category: Ingraham, H A.]]
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[[Category: Guy RK]]
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[[Category: Juzumiene, D.]]
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[[Category: Ingraham HA]]
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[[Category: Krylova, I N.]]
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[[Category: Juzumiene D]]
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[[Category: Lebedeva, L.]]
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[[Category: Krylova IN]]
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[[Category: MacKay, J A.]]
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[[Category: Lebedeva L]]
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[[Category: Madauss, K.]]
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[[Category: MacKay JA]]
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[[Category: Montana, V.]]
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[[Category: Madauss K]]
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[[Category: Moore, J.]]
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[[Category: Montana V]]
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[[Category: Sablin, E P.]]
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[[Category: Moore J]]
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[[Category: Suzawa, M.]]
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[[Category: Sablin EP]]
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[[Category: Thornton, J W.]]
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[[Category: Suzawa M]]
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[[Category: Waitt, G M.]]
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[[Category: Thornton JW]]
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[[Category: Williams, J D.]]
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[[Category: Waitt GM]]
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[[Category: Williams, S P.]]
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[[Category: Williams JD]]
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[[Category: Willson, T M.]]
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[[Category: Williams SP]]
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[[Category: Xu, R X.]]
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[[Category: Willson TM]]
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[[Category: Lrh-1]]
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[[Category: Xu RX]]
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[[Category: Phosphatidylglycerol]]
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[[Category: Tif-1]]
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[[Category: Transcription]]
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Current revision

crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol

PDB ID 1yok

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