1z77

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1z77" [edit=sysop:move=sysop])
Current revision (00:43, 21 November 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1z77.png|left|200px]]
 
-
{{STRUCTURE_1z77| PDB=1z77 | SCENE= }}
+
==Crystal structure of transcriptional regulator protein from Thermotoga maritima.==
 +
<StructureSection load='1z77' size='340' side='right'caption='[[1z77]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1z77]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z77 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z77 OCA], [https://pdbe.org/1z77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z77 RCSB], [https://www.ebi.ac.uk/pdbsum/1z77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z77 ProSAT], [https://www.topsan.org/Proteins/MCSG/1z77 TOPSAN]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q9X0C0_THEMA Q9X0C0_THEMA]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z77_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z77 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained.
-
===Crystal structure of transcriptional regulator protein from Thermotoga maritima.===
+
Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment.,Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W J Struct Biol. 2007 Sep;159(3):424-32. Epub 2007 May 16. PMID:17588774<ref>PMID:17588774</ref>
-
{{ABSTRACT_PUBMED_17588774}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1z77" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[1z77]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z77 OCA].
+
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
-
 
+
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:017588774</ref><references group="xtra"/>
+
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
-
[[Category: Chruszcz, M.]]
+
[[Category: Chruszcz M]]
-
[[Category: Cymborowski, M.]]
+
[[Category: Cymborowski M]]
-
[[Category: Koclega, K D.]]
+
[[Category: Koclega KD]]
-
[[Category: Kudritska, M.]]
+
[[Category: Kudritska M]]
-
[[Category: MCSG, Midwest Center for Structural Genomics.]]
+
[[Category: Minor W]]
-
[[Category: Minor, W.]]
+
[[Category: Zimmerman MD]]
-
[[Category: Zimmerman, M D.]]
+
-
[[Category: Mcsg]]
+
-
[[Category: Midwest center for structural genomic]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Tetr family]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcriptional regulator]]
+

Current revision

Crystal structure of transcriptional regulator protein from Thermotoga maritima.

PDB ID 1z77

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z77"
Personal tools