1ycl

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[[Image:1ycl.png|left|200px]]
 
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{{STRUCTURE_1ycl| PDB=1ycl | SCENE= }}
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==Crystal Structure of B. subtilis LuxS in Complex with a Catalytic 2-Ketone Intermediate==
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<StructureSection load='1ycl' size='340' side='right'caption='[[1ycl]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Crystal Structure of B. subtilis LuxS in Complex with a Catalytic 2-Ketone Intermediate===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ycl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YCL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15751951}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=KRI:(S)-2-AMINO-4-[(2S,3R)-2,3,5-TRIHYDROXY-4-OXO-PENTYL]MERCAPTO-BUTYRIC+ACID'>KRI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ycl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ycl OCA], [https://pdbe.org/1ycl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ycl RCSB], [https://www.ebi.ac.uk/pdbsum/1ycl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ycl ProSAT]</span></td></tr>
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[[1ycl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YCL OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/LUXS_BACSU LUXS_BACSU] Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).[HAMAP-Rule:MF_00091]
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<ref group="xtra">PMID:015751951</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1ycl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ycl ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Bell, C E.]]
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[[Category: Large Structures]]
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[[Category: Hu, X.]]
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[[Category: Bell CE]]
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[[Category: Pei, D.]]
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[[Category: Hu X]]
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[[Category: Rajan, R.]]
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[[Category: Pei D]]
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[[Category: Zhu, J.]]
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[[Category: Rajan R]]
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[[Category: Hydrolase]]
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[[Category: Zhu J]]
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[[Category: Metalloenzyme]]
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[[Category: Quorum sensing]]
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Current revision

Crystal Structure of B. subtilis LuxS in Complex with a Catalytic 2-Ketone Intermediate

PDB ID 1ycl

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