1zms
From Proteopedia
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| - | [[Image:1zms.png|left|200px]] | ||
| - | + | ==LMP1 Protein binds to TRAF3 as a structural CD40== | |
| + | <StructureSection load='1zms' size='340' side='right'caption='[[1zms]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1zms]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_RAJI Human herpesvirus 4 strain RAJI]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZMS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zms OCA], [https://pdbe.org/1zms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zms RCSB], [https://www.ebi.ac.uk/pdbsum/1zms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zms ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN] Defects in TRAF3 are the cause of susceptibility to herpes simplex encephalitis 3 (HSE3) [MIM:[https://omim.org/entry/614849 614849]. A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.<ref>PMID:20832341</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN] Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.<ref>PMID:15383523</ref> <ref>PMID:15084608</ref> <ref>PMID:17991829</ref> <ref>PMID:20097753</ref> <ref>PMID:20185819</ref> <ref>PMID:19937093</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zm/1zms_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zms ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | [[ | + | </StructureSection> |
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| - | == | + | |
| - | < | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bishop | + | [[Category: Human herpesvirus 4 strain RAJI]] |
| - | [[Category: Ely | + | [[Category: Large Structures]] |
| - | [[Category: Li | + | [[Category: Bishop GA]] |
| - | [[Category: Ni | + | [[Category: Ely KR]] |
| - | [[Category: Reed | + | [[Category: Li C]] |
| - | [[Category: Satterthwait | + | [[Category: Ni C-Z]] |
| - | [[Category: Welsh | + | [[Category: Reed JC]] |
| - | [[Category: Wu | + | [[Category: Satterthwait AC]] |
| - | [[Category: Xie | + | [[Category: Welsh K]] |
| - | [[Category: Zhu | + | [[Category: Wu SD]] |
| - | + | [[Category: Xie P]] | |
| - | + | [[Category: Zhu X]] | |
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Current revision
LMP1 Protein binds to TRAF3 as a structural CD40
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Categories: Homo sapiens | Human herpesvirus 4 strain RAJI | Large Structures | Bishop GA | Ely KR | Li C | Ni C-Z | Reed JC | Satterthwait AC | Welsh K | Wu SD | Xie P | Zhu X
