1zb1

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[[Image:1zb1.png|left|200px]]
 
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{{STRUCTURE_1zb1| PDB=1zb1 | SCENE= }}
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==Structure basis for endosomal targeting by the Bro1 domain==
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<StructureSection load='1zb1' size='340' side='right'caption='[[1zb1]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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===Structure basis for endosomal targeting by the Bro1 domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zb1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZB1 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15935782}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zb1 OCA], [https://pdbe.org/1zb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zb1 RCSB], [https://www.ebi.ac.uk/pdbsum/1zb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zb1 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1zb1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZB1 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/BRO1_YEAST BRO1_YEAST] Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. Fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen. Acts as an adapter that recruits the DOA4 deubiquitinase to the endosomes, leading to deubiquitination of cargo proteins prior to the lumenal sequestration. Its association to the endosomes depends on SNF7 and its dissociation requires VPS4. Interacts functionally with the Pkc1p-mitogen-activated protein kinase pathway.<ref>PMID:8649366</ref> <ref>PMID:11454748</ref> <ref>PMID:12062418</ref> <ref>PMID:12668726</ref> <ref>PMID:14523026</ref> <ref>PMID:15326198</ref>
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:015935782</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zb/1zb1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zb1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Beach, B M.]]
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[[Category: Beach BM]]
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[[Category: Hierro, A.]]
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[[Category: Hierro A]]
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[[Category: Hurley, J H.]]
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[[Category: Hurley JH]]
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[[Category: Kim, J.]]
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[[Category: Kim J]]
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[[Category: Odorizzi, G.]]
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[[Category: Odorizzi G]]
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[[Category: Sitaraman, S.]]
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[[Category: Sitaraman S]]
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[[Category: Aip1]]
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[[Category: Bro1]]
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[[Category: Bro1 domain]]
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[[Category: Protein transport]]
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[[Category: Snf7]]
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[[Category: Trafficking]]
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Current revision

Structure basis for endosomal targeting by the Bro1 domain

PDB ID 1zb1

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