1yp0

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[[Image:1yp0.png|left|200px]]
 
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{{STRUCTURE_1yp0| PDB=1yp0 | SCENE= }}
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==Structure of the steroidogenic factor-1 ligand binding domain bound to phospholipid and a SHP peptide motif==
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<StructureSection load='1yp0' size='340' side='right'caption='[[1yp0]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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===Structure of the steroidogenic factor-1 ligand binding domain bound to phospholipid and a SHP peptide motif===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yp0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YP0 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15721253}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEF:DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE'>PEF</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yp0 OCA], [https://pdbe.org/1yp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yp0 RCSB], [https://www.ebi.ac.uk/pdbsum/1yp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yp0 ProSAT]</span></td></tr>
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[[1yp0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP0 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/STF1_MOUSE STF1_MOUSE] Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.<ref>PMID:17210646</ref> <ref>PMID:18988706</ref>
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<ref group="xtra">PMID:015721253</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yp/1yp0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yp0 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bingham, N.]]
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[[Category: Rattus norvegicus]]
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[[Category: Cavey, G.]]
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[[Category: Bingham N]]
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[[Category: Choi, M.]]
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[[Category: Cavey G]]
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[[Category: Daugherty, J.]]
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[[Category: Choi M]]
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[[Category: Kliewer, S.]]
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[[Category: Daugherty J]]
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[[Category: Kovach, A.]]
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[[Category: Kliewer S]]
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[[Category: Li, Y.]]
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[[Category: Kovach A]]
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[[Category: Suino, K.]]
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[[Category: Li Y]]
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[[Category: Xu, H.]]
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[[Category: Suino K]]
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[[Category: Helical sandwich fold]]
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[[Category: Xu H]]
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[[Category: Lbd fold]]
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[[Category: Ligand dependent nuclear receptor]]
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[[Category: Nr5a1]]
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[[Category: Steroidogenic factor-1]]
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[[Category: Transcription]]
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Current revision

Structure of the steroidogenic factor-1 ligand binding domain bound to phospholipid and a SHP peptide motif

PDB ID 1yp0

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Proteopedia Page Contributors and Editors (what is this?)

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