1zwg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:13, 15 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1zwg.png|left|200px]]
 
-
{{STRUCTURE_1zwg| PDB=1zwg | SCENE= }}
+
==SUCCINYL HUMAN PARATHYROID HORMONE 4-37, NMR, 10 STRUCTURES==
-
 
+
<StructureSection load='1zwg' size='340' side='right'caption='[[1zwg]]' scene=''>
-
===SUCCINYL HUMAN PARATHYROID HORMONE 4-37, NMR, 10 STRUCTURES===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1zwg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZWG FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_10623601}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zwg OCA], [https://pdbe.org/1zwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zwg RCSB], [https://www.ebi.ac.uk/pdbsum/1zwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zwg ProSAT]</span></td></tr>
-
[[1zwg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWG OCA].
+
</table>
-
 
+
== Disease ==
-
==Reference==
+
[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN] Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:[https://omim.org/entry/146200 146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.<ref>PMID:2212001</ref> <ref>PMID:10523031</ref> <ref>PMID:18056632</ref>
-
<ref group="xtra">PMID:010623601</ref><references group="xtra"/>
+
== Function ==
 +
[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN] PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.<ref>PMID:21076856</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zw/1zwg_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zwg ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Marx, U C.]]
+
[[Category: Large Structures]]
-
[[Category: Roesch, P.]]
+
[[Category: Marx UC]]
-
[[Category: Disease mutation]]
+
[[Category: Roesch P]]
-
[[Category: Hormone]]
+

Current revision

SUCCINYL HUMAN PARATHYROID HORMONE 4-37, NMR, 10 STRUCTURES

PDB ID 1zwg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zwg"
Personal tools