1yiz

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[[Image:1yiz.png|left|200px]]
 
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{{STRUCTURE_1yiz| PDB=1yiz | SCENE= }}
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==Aedes aegypti kynurenine aminotrasferase==
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<StructureSection load='1yiz' size='340' side='right'caption='[[1yiz]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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===Aedes aegypti kynurenine aminotrasferase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yiz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YIZ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15853804}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yiz OCA], [https://pdbe.org/1yiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yiz RCSB], [https://www.ebi.ac.uk/pdbsum/1yiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yiz ProSAT]</span></td></tr>
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[[1yiz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIZ OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/KAT_AEDAE KAT_AEDAE] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) (PubMed:12110301, PubMed:15556614). Also catalyzes the irreversible transamination of several amino acids including cysteine, tyrosine, glutamine, methionine, histidine and phenylalanine (PubMed:15556614). Can use various keto-acids as the amino group acceptor (PubMed:15556614, PubMed:12110301).<ref>PMID:12110301</ref> <ref>PMID:15556614</ref>
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<ref group="xtra">PMID:015853804</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yi/1yiz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yiz ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Aedes aegypti]]
[[Category: Aedes aegypti]]
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[[Category: Ding, H.]]
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[[Category: Large Structures]]
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[[Category: Gao, Y G.]]
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[[Category: Ding H]]
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[[Category: Han, Q.]]
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[[Category: Gao YG]]
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[[Category: Li, J.]]
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[[Category: Han Q]]
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[[Category: Robinson, H.]]
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[[Category: Li J]]
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[[Category: Wilson, S.]]
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[[Category: Robinson H]]
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[[Category: Aede]]
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[[Category: Wilson S]]
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[[Category: Kynurenic acid]]
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[[Category: Kynurenine]]
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[[Category: Kynurenine aminotransferase]]
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[[Category: Mosquito]]
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[[Category: Plp]]
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[[Category: Plp-enzyme]]
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[[Category: Pyridoxal phosphate]]
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[[Category: Transferase]]
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Current revision

Aedes aegypti kynurenine aminotrasferase

PDB ID 1yiz

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