1yx7

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[[Image:1yx7.png|left|200px]]
 
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{{STRUCTURE_1yx7| PDB=1yx7 | SCENE= }}
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==NMR structure of Calsensin, energy minimized average structure.==
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<StructureSection load='1yx7' size='340' side='right'caption='[[1yx7]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yx7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemopis_marmorata Haemopis marmorata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YX7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yx7 OCA], [https://pdbe.org/1yx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yx7 RCSB], [https://www.ebi.ac.uk/pdbsum/1yx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yx7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CLSS_HAEMA CLSS_HAEMA] May function as a trigger protein which interacts with a larger protein. May mediate calcium-dependent signal transduction events in the growth cones and axons of a small group of sensory neurons which fasciculate in a single axon tract.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/1yx7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yx7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Calsensin is an EF-hand calcium-binding protein expressed by a subset of peripheral sensory neurons that fasciculate into a single tract in the leech central nervous system. Calsensin is a 9-kD protein with two EF-hand calcium-binding motifs. Using multidimensional NMR spectroscopy we have determined the solution structure and backbone dynamics of calcium-bound Calsensin. Calsensin consists of four helices forming a unicornate-type four-helix bundle. The residues in the third helix undergo slow conformational exchange indicating that the motion of this helix is associated with calciumbinding. The backbone dynamics of the protein as measured by (15)N relaxation rates and heteronuclear NOEs correlate well with the three-dimensional structure. Furthermore, comparison of the structure of Calsensin with other members of the EF-hand calcium-binding protein family provides insight into plausible mechanisms of calcium and target protein binding.
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===NMR structure of Calsensin, energy minimized average structure.===
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Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium-binding protein.,Venkitaramani DV, Fulton DB, Andreotti AH, Johansen KM, Johansen J Protein Sci. 2005 Jul;14(7):1894-901. Epub 2005 Jun 3. PMID:15937283<ref>PMID:15937283</ref>
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{{ABSTRACT_PUBMED_15937283}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1yx7" style="background-color:#fffaf0;"></div>
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[[1yx7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemopis_marmorata Haemopis marmorata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX7 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015937283</ref><references group="xtra"/>
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</StructureSection>
[[Category: Haemopis marmorata]]
[[Category: Haemopis marmorata]]
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[[Category: Andreotti, A H.]]
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[[Category: Large Structures]]
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[[Category: Fulton, D B.]]
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[[Category: Andreotti AH]]
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[[Category: Johansen, J.]]
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[[Category: Fulton DB]]
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[[Category: Johansen, K M.]]
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[[Category: Johansen J]]
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[[Category: Venkitaramani, D V.]]
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[[Category: Johansen KM]]
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[[Category: Calcium-binding protein ef-hand]]
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[[Category: Venkitaramani DV]]
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[[Category: Calsensin]]
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[[Category: Helix-loop-helix]]
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[[Category: Metal binding protein]]
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[[Category: Nervous system]]
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Current revision

NMR structure of Calsensin, energy minimized average structure.

PDB ID 1yx7

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