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1z3i

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[[Image:1z3i.png|left|200px]]
 
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{{STRUCTURE_1z3i| PDB=1z3i | SCENE= }}
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==Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54==
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<StructureSection load='1z3i' size='340' side='right'caption='[[1z3i]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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===Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3I FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15806108}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3i OCA], [https://pdbe.org/1z3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3i RCSB], [https://www.ebi.ac.uk/pdbsum/1z3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3i ProSAT]</span></td></tr>
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[[1z3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3I OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/RAD54_DANRE RAD54_DANRE] Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:30961891). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity).[UniProtKB:P32863]<ref>PMID:30961891</ref>
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<ref group="xtra">PMID:015806108</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z3i ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Alexeev, A A.]]
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[[Category: Large Structures]]
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[[Category: Czyzewski, B K.]]
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[[Category: Alexeev AA]]
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[[Category: Kowalczykowski, S C.]]
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[[Category: Czyzewski BK]]
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[[Category: Mazin, A V.]]
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[[Category: Kowalczykowski SC]]
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[[Category: Pavletich, N P.]]
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[[Category: Mazin AV]]
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[[Category: Thoma, N H.]]
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[[Category: Pavletich NP]]
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[[Category: Recombination atpase helicase]]
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[[Category: Thoma NH]]
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[[Category: Recombination-dna binding complex]]
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Current revision

Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54

PDB ID 1z3i

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