2co8

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[[Image:2co8.png|left|200px]]
 
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{{STRUCTURE_2co8| PDB=2co8 | SCENE= }}
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==Solution structures of the LIM domain of human NEDD9 interacting protein with calponin homology and LIM domains==
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<StructureSection load='2co8' size='340' side='right'caption='[[2co8]]' scene=''>
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===Solution structures of the LIM domain of human NEDD9 interacting protein with calponin homology and LIM domains===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2co8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CO8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[2co8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CO8 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2co8 OCA], [https://pdbe.org/2co8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2co8 RCSB], [https://www.ebi.ac.uk/pdbsum/2co8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2co8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2co8 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MICA1_HUMAN MICA1_HUMAN] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.<ref>PMID:18305261</ref> <ref>PMID:21864500</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/2co8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2co8 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Koshiba S]]
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[[Category: Saito, K.]]
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[[Category: Saito K]]
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[[Category: Sato, M.]]
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[[Category: Sato M]]
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[[Category: Tomizawa, T.]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Lim domain]]
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[[Category: Metal binding protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Zinc finger protein]]
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Current revision

Solution structures of the LIM domain of human NEDD9 interacting protein with calponin homology and LIM domains

PDB ID 2co8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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