2dae

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[[Image:2dae.png|left|200px]]
 
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{{STRUCTURE_2dae| PDB=2dae | SCENE= }}
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==Solution Structure of the N-terminal CUE Domain in the Human Mitogen-activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2)==
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<StructureSection load='2dae' size='340' side='right'caption='[[2dae]]' scene=''>
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===Solution Structure of the N-terminal CUE Domain in the Human Mitogen-activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2dae]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DAE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dae OCA], [https://pdbe.org/2dae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dae RCSB], [https://www.ebi.ac.uk/pdbsum/2dae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dae ProSAT], [https://www.topsan.org/Proteins/RSGI/2dae TOPSAN]</span></td></tr>
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[[2dae]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DAE OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TAB2_HUMAN TAB2_HUMAN] Defects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:[https://omim.org/entry/612863 612863]. It is a disease characterized by congenital developmental abnormalities involving structures of the heart. Clinical features include left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).<ref>PMID:20493459</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TAB2_HUMAN TAB2_HUMAN] Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.<ref>PMID:10882101</ref> <ref>PMID:11460167</ref> <ref>PMID:20493459</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2dae_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dae ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Koshiba S]]
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[[Category: Sato, M.]]
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[[Category: Sato M]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Zhao, C.]]
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[[Category: Zhao C]]
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[[Category: Cue domain]]
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[[Category: Kiaa0733]]
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[[Category: Map3k7ip2]]
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[[Category: Mitogen-activated protein kinase kinase kinase 7 interacting protein 2]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Unknown function]]
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Current revision

Solution Structure of the N-terminal CUE Domain in the Human Mitogen-activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2)

PDB ID 2dae

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