2art
From Proteopedia
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| - | [[Image:2art.png|left|200px]] | ||
| - | + | ==Crystal structure of lipoate-protein ligase A bound with lipoyl-AMP== | |
| - | + | <StructureSection load='2art' size='340' side='right'caption='[[2art]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2art]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ART OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ART FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=LPA:LIPOIC+ACID'>LPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2art FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2art OCA], [https://pdbe.org/2art PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2art RCSB], [https://www.ebi.ac.uk/pdbsum/2art PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2art ProSAT]</span></td></tr> |
| - | [[2art]] is a 1 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/LPLAN_THEAC LPLAN_THEAC] Part of a lipoate-protein ligase complex that catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Can also use octanoate as substrate.<ref>PMID:16141198</ref> <ref>PMID:19520844</ref> <ref>PMID:19594830</ref> |
| - | < | + | == Evolutionary Conservation == |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ar/2art_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2art ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Thermoplasma acidophilum]] | [[Category: Thermoplasma acidophilum]] | ||
| - | [[Category: Ha | + | [[Category: Ha JY]] |
| - | [[Category: Kim | + | [[Category: Kim DJ]] |
| - | [[Category: Kim | + | [[Category: Kim KH]] |
| - | [[Category: Lee | + | [[Category: Lee HH]] |
| - | [[Category: Lee | + | [[Category: Lee SJ]] |
| - | [[Category: Suh | + | [[Category: Suh SW]] |
| - | [[Category: Yoon | + | [[Category: Yoon HJ]] |
| - | + | ||
Current revision
Crystal structure of lipoate-protein ligase A bound with lipoyl-AMP
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Categories: Large Structures | Thermoplasma acidophilum | Ha JY | Kim DJ | Kim KH | Lee HH | Lee SJ | Suh SW | Yoon HJ
